A case of mixed connective tissue disease(MCTD) with trigeminal sensory neuropathy.

Trigeminal sensory neuropathy and mixed connective tissue disease: A case report

Mixed connective tissue disease (MCTD), a multisystem disorder, has features of systemic lupus erythematosus, scleroderma, and polymyositis/dermatomyositis but also a high titer of antibody to ribonucleoprotein. A 62-year-old Japanese woman with MCTD had an isolated trigeminal sensory neuropathy as an early manifestation of MCTD. Raynaud’s phenomenon occurred almost simultaneously with the neur...

[Trigeminal neuropathy and connective tissue diseases].

Connective tissue diseases are a rare and poorly understood etiology of trigeminal neuropathy. In a retrospective multicentric study covering 12 years. 12 cases were identified in the archives of the Departments of Neurology, Rheumatology and Internal Medicine: 4 were associated with progressive systemic sclerosis. 4 with mixed connective tissue diseases and 4 with Sjögren's syndrome. In 9 of t...

B cell Therapy to Treat an Axonal Neuropathy in Mixed Connective Tissue Disease

The B cell is a vital contributor to humoral immunity. The B cell-specific antigen CD20 is expressed during B cell development, starting at the pre-B cell level and persists through B cell differentiation, but is lost during terminal differentiation to plasma cells. Rituximab is a monoclonal antibody that destroys both normal and malignant B cells that have CD20 on their surfaces and is ther...

A Case and Literature Review of Normal Pressure Hydrocephalus in Mixed Connective Tissue Disease

Normal Pressure hydrocephalus (NPH) is characterized by gait apraxia, urinary incontinence, and dementia. Mixed connective tissue disease (MCTD) is an autoimmune connective tissue disease that has never been reported to cause NPH. Our patient was a 67-year man with a one-year history of gradual worsening gait and balance, urinary urgency with urge incontinence and decreased short-term memory. P...

A case of mixed connective tissue disease combined with sarcoidosis.